The inception of the first Salesian educational venture in Calcutta marked the establishment of Don Bosco Liluah. Urged by the Archbishop of Calcutta, the Salesians embarked on creating a technical school to serve the underprivileged population. Initially focusing on educating impoverished Anglo-Indian boys, the property was acquired in 1927, but formal operations commenced a decade later, on the Feast of the Immaculate Conception. At the Archbishop's suggestion, the Salesians also initiated a parish dedicated to Don Bosco in anticipation of his beatification.

Presently, Don Bosco Liluah stands as a comprehensive institution encompassing a fully-equipped technical school offering formal and non-formal technical training, an academic school, boarding facilities for economically disadvantaged youth, a night school, coaching center, adult education facility, vocational training center, and community outreach programs.

The concurrent establishment of the parish, alongside the technical school, aimed to address the spiritual needs of European and Anglo-Indian Catholics residing in the Liluah Railway Colony. Over time, the parish has evolved into a sizable community with over 2,000 Catholics representing diverse ethnic and linguistic backgrounds, along with four satellite stations. Its core activities include fostering spiritual growth, engaging in developmental projects, and providing educational support to children and families in need.